Ontology highlight
ABSTRACT:
SUBMITTER: Jiang Y
PROVIDER: S-EPMC4496226 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Jiang Yuan Y Zhu Ying Y Wang Xinxin X Gong Juan J Hu Chunyan C Guo Bo B Zhu Bo B Li Yongsheng Y
Oncotarget 20150401 11
Regulations between NF-κB and HIF-1 have not been adequately addressed in previous research. Here, we report that hypoxia increased NF-κB in hepatocellular carcinoma cells. The HIF-1 protein level was rapidly induced by protein stabilization (by 2 hours) and then moderately decreased, whereas mRNA levels were reciprocally increased. We also found that NF-κB p50 and p65 (RelA), but not c-Rel, bound the HIF-1a promoter, thus increasing its transcription. In contrast, miR-199a-5p and miR-93, c-Rel ...[more]