Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion.
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ABSTRACT:
SUBMITTER: Roselli S
PROVIDER: S-EPMC4496368 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion.
Roselli Séverine S Pundavela Jay J Demont Yohann Y Faulkner Sam S Keene Sheridan S Attia John J Jiang Chen Chen CC Zhang Xu Dong XD Walker Marjorie M MM Hondermarck Hubert H
Oncotarget 20150401 12
The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed by immunohistochemistry in a series of 318 clinically annotated breast cancers and 53 normal breast tissues. Sortilin was detected in epithelial cells, with increased levels in cancers, as compared to normal tissues (p = 0.0088). It was found in 79% of invasive ductal carcinomas and 54% of invasive lobular carcinomas ( ...[more]
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