Ontology highlight
ABSTRACT:
SUBMITTER: Teilum K
PROVIDER: S-EPMC4496568 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Teilum Kaare K Olsen Johan G JG Kragelund Birthe B BB
Frontiers in molecular biosciences 20150709
In biology proteins from different structural classes interact across and within classes in ways that are optimized to achieve balanced functional outputs. The interactions between intrinsically disordered proteins (IDPs) and other proteins rely on changes in flexibility and this is seen as a strong determinant for their function. This has fostered the notion that IDP's bind with low affinity but high specificity. Here we have analyzed available detailed thermodynamic data for protein-protein in ...[more]