Unknown

Dataset Information

0

In vivo efficacy and molecular docking of designed peptide that exhibits potent antipneumococcal activity and synergises in combination with penicillin.

ABSTRACT: We have previously designed a series of antimicrobial peptides (AMPs) and in the current study, the in vivo therapeutic efficacy and toxicity were investigated. Among all the peptides, DM3 conferred protection to a substantial proportion of the lethally infected mice caused by a strain of penicillin-resistant Streptococcus pneumoniae. Synergism was reported and therapeutic efficacy was significantly enhanced when DM3 was formulated in combination with penicillin (PEN). No toxicity was observed in mice receiving these treatments. The in silico molecular docking study results showed that, DM3 has a strong affinity towards three protein targets; autolysin and pneumococcal surface protein A (pspA). Thus AMPs could serve as supporting therapeutics in combination with conventional antibiotics to enhance treatment outcome.

SUBMITTER: Le CF 

PROVIDER: S-EPMC4496672 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

In vivo efficacy and molecular docking of designed peptide that exhibits potent antipneumococcal activity and synergises in combination with penicillin.

Le Cheng-Foh CF   Yusof Mohd Yasim Mohd MY   Hassan Mahmood Ameen Abdulla MA   Lee Vannajan Sanghiran VS   Isa Diyana Mohd DM   Sekaran Shamala Devi SD  

Scientific reports 20150709

We have previously designed a series of antimicrobial peptides (AMPs) and in the current study, the in vivo therapeutic efficacy and toxicity were investigated. Among all the peptides, DM3 conferred protection to a substantial proportion of the lethally infected mice caused by a strain of penicillin-resistant Streptococcus pneumoniae. Synergism was reported and therapeutic efficacy was significantly enhanced when DM3 was formulated in combination with penicillin (PEN). No toxicity was observed i  ...[more]

Similar Datasets

Unknown In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin.
| S-EPMC4434909 | biostudies-literature
Unknown A Designed Analog of an Antimicrobial Peptide, Crabrolin, Exhibits Enhanced Anti-Proliferative and In Vivo Antimicrobial Activity.
| S-EPMC10572522 | biostudies-literature
Unknown Anti-cancer small molecule JP-8g exhibits potent in vivo anti-inflammatory activity.
| S-EPMC3953725 | biostudies-literature
Unknown Scorpion Peptide Smp24 Exhibits a Potent Antitumor Effect on Human Lung Cancer Cells by Damaging the Membrane and Cytoskeleton In Vivo and In Vitro.
| S-EPMC9318729 | biostudies-literature
Unknown Cetylpyridinium Chloride (CPC) Exhibits Potent, Rapid Activity Against Influenza Viruses in vitro and in vivo.
| S-EPMC5605151 | biostudies-literature
Unknown Berbamine exhibits potent antitumor effects on imatinib-resistant CML cells in vitro and in vivo.
| S-EPMC4002272 | biostudies-literature
Transcriptomics Micronanoparticled risedronate exhibits potent vaccine adjuvant effects
2024-08-01 | GSE239649 | GEO
Unknown A novel, rationally designed, hybrid antimicrobial peptide, inspired by cathelicidin and aurein, exhibits membrane-active mechanisms against Pseudomonas aeruginosa.
| S-EPMC7272617 | biostudies-literature
Unknown NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia.
| S-EPMC5349906 | biostudies-literature
Unknown (-)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo.
| S-EPMC5995859 | biostudies-literature