Ontology highlight
ABSTRACT:
SUBMITTER: Staniland S
PROVIDER: S-EPMC4497317 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Staniland Samantha S Yuan Bo B Giménez-Agulló Nelson N Marcelli Tommaso T Willies Simon C SC Grainger Damian M DM Turner Nicholas J NJ Clayden Jonathan J
Chemistry (Weinheim an der Bergstrasse, Germany) 20140822 41
Atropisomeric biaryls carrying ortho-hydroxymethyl and formyl groups were made enantioselectively by desymmetrisation of dialdehyde or diol substrates. The oxidation of the symmetrical diol substrates was achieved using a variant of galactose oxidase (GOase), and the reduction of the dialdehydes using a panel of ketoreductases. Either M or P enantiomers of the products could be formed, with absolute configurations assigned by time-dependent DFT calculations of circular dichroism spectra. The dif ...[more]