Ontology highlight
ABSTRACT:
SUBMITTER: Jors S
PROVIDER: S-EPMC4497753 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Jörs Simone S Jeliazkova Petia P Ringelhan Marc M Thalhammer Julian J Dürl Stephanie S Ferrer Jorge J Sander Maike M Heikenwalder Mathias M Schmid Roland M RM Siveke Jens T JT Geisler Fabian F
The Journal of clinical investigation 20150427 6
Ductular reactions (DRs) are observed in virtually all forms of human liver disease; however, the histogenesis and function of DRs in liver injury are not entirely understood. It is widely believed that DRs contain bipotential liver progenitor cells (LPCs) that serve as an emergency cell pool to regenerate both cholangiocytes and hepatocytes and may eventually give rise to hepatocellular carcinoma (HCC). Here, we used a murine model that allows highly efficient and specific lineage labeling of t ...[more]