The human IgE repertoire.
Ontology highlight
ABSTRACT:
SUBMITTER: Gadermaier E
PROVIDER: S-EPMC4497803 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
The human IgE repertoire.
Gadermaier Elisabeth E Levin Mattias M Flicker Sabine S Ohlin Mats M
International archives of allergy and immunology 20131130 2
IgE is a key mediator in allergic diseases. However, in strong contrast to other antibody isotypes, many details of the composition of the human IgE repertoire are poorly defined. The low levels of human IgE in the circulation and the rarity of IgE-producing B cells are important reasons for this lack of knowledge. In this review, we summarize the current knowledge on these repertoires both in terms of their complexity and activity, i.e. knowledge which despite the difficulties encountered when ...[more]
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