Ontology highlight
ABSTRACT:
SUBMITTER: de March CA
PROVIDER: S-EPMC4497840 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
de March Claire A CA Yu Yiqun Y Ni Mengjue J MJ Adipietro Kaylin A KA Matsunami Hiroaki H Ma Minghong M Golebiowski Jérôme J
Journal of the American Chemical Society 20150629 26
Odorant receptor (OR) genes and proteins represent more than 2% of our genome and 4% of our proteome and constitute the largest subgroup of G protein-coupled receptors (GPCRs). The mechanism underlying OR activation remains poorly understood, as they do not share some of the highly conserved motifs critical for activation of non-olfactory GPCRs. By combining site-directed mutagenesis, heterologous expression, and molecular dynamics simulations that capture the conformational change of constituti ...[more]