Ontology highlight
ABSTRACT:
SUBMITTER: Muratcioglu S
PROVIDER: S-EPMC4497850 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20150604 7
Ras proteins recruit and activate effectors, including Raf, that transmit receptor-initiated signals. Monomeric Ras can bind Raf; however, activation of Raf requires its dimerization. It has been suspected that dimeric Ras may promote dimerization and activation of Raf. Here, we show that the GTP-bound catalytic domain of K-Ras4B, a highly oncogenic splice variant of the K-Ras isoform, forms stable homodimers. We observe two major dimer interfaces. The first, highly populated β-sheet dimer inter ...[more]