Ontology highlight
ABSTRACT:
SUBMITTER: Bhanot H
PROVIDER: S-EPMC4497855 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Bhanot Haymanti H Reddy Mamatha M MM Nonami Atsushi A Weisberg Ellen L EL Bonal Dennis D Kirschmeier Paul T PT Salgia Sabrina S Podar Klaus K Galinsky Ilene I Chowdary Tirumala K TK Neuberg Donna D Tonon Giovanni G Stone Richard M RM Asara John J Griffin James D JD Sattler Martin M
Leukemia 20150223 7
The rapid proliferation of myeloid leukemia cells is highly dependent on increased glucose metabolism. Through an unbiased metabolomics analysis of leukemia cells, we found that the glycogenic precursor UDP-D-glucose is pervasively upregulated, despite low glycogen levels. Targeting the rate-limiting glycogen synthase 1 (GYS1) not only decreased glycolytic flux but also increased activation of the glycogen-responsive AMP kinase (AMPK), leading to significant growth suppression. Further, genetic ...[more]