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Prospective cohort study with active surveillance for fever in four dengue endemic countries in Latin America.


ABSTRACT: To prepare for a Phase III dengue vaccine efficacy trial, 20 investigational sites were selected for this observational study to identify dengue infections in a closed cohort (N = 3,000 children 9-16 years of age). Of 255 acute febrile episodes experienced by 235 children, 50 (21.3%) were considered serologically probable dengue, and 18 (7.7%) were considered virologically confirmed (i.e., dengue NS1 antigen positive) dengue cases. Considering the disease-free and at-risk period from study start to onset of symptoms, the overall incidence density of acute febrile episodes was 17.7 per 100 person-years of follow-up, ranging from 15.3 in Colombia to 22.0 in Puerto Rico. This study showed that all sites were capable of capturing and following up acute febrile episodes within a specific timeframe among the established cohort and to detect dengue cases.

SUBMITTER: Dayan G 

PROVIDER: S-EPMC4497892 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Prospective cohort study with active surveillance for fever in four dengue endemic countries in Latin America.

Dayan Gustavo G   Arredondo Jose L JL   Carrasquilla Gabriel G   Deseda Carmen C CC   Dietze Reynaldo R   Luz Kleber K   Costa Maria Selma N MSN   Cunha Rivaldo V RV   Rey Luis C LC   Morales Javier J   Reynales Humberto H   Miranda Maria M   Zambrano Betzana B   Rivas Enrique E   Garbes Pedro P   Noriega Fernando F  

The American journal of tropical medicine and hygiene 20150526 1


To prepare for a Phase III dengue vaccine efficacy trial, 20 investigational sites were selected for this observational study to identify dengue infections in a closed cohort (N = 3,000 children 9-16 years of age). Of 255 acute febrile episodes experienced by 235 children, 50 (21.3%) were considered serologically probable dengue, and 18 (7.7%) were considered virologically confirmed (i.e., dengue NS1 antigen positive) dengue cases. Considering the disease-free and at-risk period from study start  ...[more]

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