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Actin Mechanics and Fragmentation.


ABSTRACT: Cell physiological processes require the regulation and coordination of both mechanical and dynamical properties of the actin cytoskeleton. Here we review recent advances in understanding the mechanical properties and stability of actin filaments and how these properties are manifested at larger (network) length scales. We discuss how forces can influence local biochemical interactions, resulting in the formation of mechanically sensitive dynamic steady states. Understanding the regulation of such force-activated chemistries and dynamic steady states reflects an important challenge for future work that will provide valuable insights as to how the actin cytoskeleton engenders mechanoresponsiveness of living cells.

SUBMITTER: De La Cruz EM 

PROVIDER: S-EPMC4498053 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Actin Mechanics and Fragmentation.

De La Cruz Enrique M EM   Gardel Margaret L ML  

The Journal of biological chemistry 20150508 28


Cell physiological processes require the regulation and coordination of both mechanical and dynamical properties of the actin cytoskeleton. Here we review recent advances in understanding the mechanical properties and stability of actin filaments and how these properties are manifested at larger (network) length scales. We discuss how forces can influence local biochemical interactions, resulting in the formation of mechanically sensitive dynamic steady states. Understanding the regulation of su  ...[more]

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