Ontology highlight
ABSTRACT:
SUBMITTER: Liao X
PROVIDER: S-EPMC4498471 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Liao Xiaoli X Rabideau Amy E AE Pentelute Bradley L BL
Chembiochem : a European journal of chemical biology 20140922 16
Antibody mimics have significant scientific and therapeutic utility for the disruption of protein-protein interactions inside cells; however, their delivery to the cell cytosol remains a major challenge. Here we show that protective antigen (PA), a component of anthrax toxin, efficiently transports commonly used antibody mimics to the cytosol of mammalian cells when conjugated to the N-terminal domain of LF (LFN). In contrast, a cell-penetrating peptide (CPP) was not able to deliver any of these ...[more]