Ontology highlight
ABSTRACT:
SUBMITTER: Schlemmer C
PROVIDER: S-EPMC4498494 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Schlemmer Claudine C Wiebe Christine C Ferenc Dorota D Kowalczyk Danuta D Wedepohl Stefanie S Ziegelmüller Patrick P Dernedde Jens J Opatz Till T
Chemistry, an Asian journal 20140530 8
Functional mimetics of the sialyl Lewis(X) tetrasaccharide were prepared by the enzymatic sialylation of a 1,3-diglycosylated indole and a glycosyl azide, which was subsequently transformed into a 1,4-diglycosylated 1,2,3-triazole, by using the trans-sialidase of Trypanosoma cruzi. These compounds inhibited the binding of E-, L-, and P-selectin-coated nanoparticles to polyacrylamide-bound sialyl-Lewis(X) -containing neighboring sulfated tyrosine residues (sTyr/sLe(X) -PAA) at low or sub-millimol ...[more]