Dataset Information

Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy.

ABSTRACT:

Background

Antipsychotic medications are increasingly used during pregnancy. Nevertheless, fetal risks are still not fully studied. It is currently unclear whether the antipsychotic treatment might induce a higher risk of fetal death. We aimed to determine if use of antipsychotic medication during pregnancy is associated with an increased risk of spontaneous abortion or stillbirth.

Methods

In a historical cohort study, we identified all clinically recognized pregnancies registered in the nationwide Danish registries from 1997 to 2008 (N = 1,005,319). Exposure was defined as any prescription of antipsychotic medications redeemed by the pregnant women during the exposure window, and recorded in the Danish National Prescription Register. Outcome was defined as any spontaneous abortion or stillbirth recorded in the Danish National Hospital Register and the Danish Medical Birth Register respectively.

Results

Women exposed to antipsychotic medications during pregnancy had a 34% higher risk of spontaneous abortion (adjusted relative risk = 1.34; 95% confidence interval = 1.22; 1.46) compared to unexposed women, but a similar risk compared to women exposed prior to (but not during) pregnancy (adjusted relative risk = 1.04; 95% confidence interval = 0.93; 1.17). The risk of spontaneous abortion was not increased in exposed pregnancies when compared to unexposed pregnancies in the same women (adjusted hazard ratio = 1.11; 95% CI = 0.94; 1.31). A twofold higher risk of stillbirth was found in women exposed to antipsychotic medications compared with unexposed women (relative risk = 2.27; 95% confidence interval = 1.45; 3.55) and compared with women exposed only prior to pregnancy (relative risk = 2.06; 95% confidence interval = 1.01; 4.19).

Conclusions

The increased risk of spontaneous abortion found in women treated with antipsychotic medications during pregnancy is most likely due to confounding factors. The risk of stillbirth was twofold higher in pregnancies exposed to antipsychotic medication during pregnancy. Treatment with antipsychotic medications during pregnancy requires careful consideration.

SUBMITTER: Sorensen MJ

PROVIDER: S-EPMC4498617 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy.

Sørensen Merete Juul MJ Kjaersgaard Maiken Ina Siegismund MI Pedersen Henrik Søndergaard HS Vestergaard Mogens M Christensen Jacob J Olsen Jørn J Parner Erik E Pedersen Lars Henning LH Bech Bodil Hammer BH

PloS one 20150710 7

<h4>Background</h4>Antipsychotic medications are increasingly used during pregnancy. Nevertheless, fetal risks are still not fully studied. It is currently unclear whether the antipsychotic treatment might induce a higher risk of fetal death. We aimed to determine if use of antipsychotic medication during pregnancy is associated with an increased risk of spontaneous abortion or stillbirth.<h4>Methods</h4>In a historical cohort study, we identified all clinically recognized pregnancies registered ...[more]

PMID: 26162087

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Dataset Information

Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy.

Background

Methods

Results

Conclusions

Publications

Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy.

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