Ontology highlight
ABSTRACT:
SUBMITTER: Fortna A
PROVIDER: S-EPMC449870 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Fortna Andrew A Kim Young Y MacLaren Erik E Marshall Kriste K Hahn Gretchen G Meltesen Lynne L Brenton Matthew M Hink Raquel R Burgers Sonya S Hernandez-Boussard Tina T Karimpour-Fard Anis A Glueck Deborah D McGavran Loris L Berry Rebecca R Pollack Jonathan J Sikela James M JM
PLoS biology 20040713 7
Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several hominoid lineages. Interspecies cDNA array-based comparative genomic hybridization was used to individually compare copy number variation for 39,711 cDNAs, representing 29,619 human gene ...[more]