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Prolonged neuropsychiatric effects following management of chloroquine intoxication with psychotropic polypharmacy.


ABSTRACT: Susceptibility to quinoline antimalarial intoxication may reflect individual genetic and drug-induced variation in neuropharmacokinetics. In this report, we describe a case of chloroquine intoxication that appeared to be prolonged by subsequent use of multiple psychotropic medications. This case highlights important new considerations for the management of quinoline antimalarial intoxication.

SUBMITTER: Maxwell NM 

PROVIDER: S-EPMC4498847 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Prolonged neuropsychiatric effects following management of chloroquine intoxication with psychotropic polypharmacy.

Maxwell Nicole M NM   Nevin Remington L RL   Stahl Stephen S   Block Jerald J   Shugarts Sarah S   Wu Alan H B AH   Dominy Stephen S   Solano-Blanco Miguel Alonso MA   Kappelman-Culver Sharon S   Lee-Messer Christopher C   Maldonado Jose J   Maxwell Andrew J AJ  

Clinical case reports 20150409 6


Susceptibility to quinoline antimalarial intoxication may reflect individual genetic and drug-induced variation in neuropharmacokinetics. In this report, we describe a case of chloroquine intoxication that appeared to be prolonged by subsequent use of multiple psychotropic medications. This case highlights important new considerations for the management of quinoline antimalarial intoxication. ...[more]

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