Ontology highlight
ABSTRACT:
SUBMITTER: Sanders RW
PROVIDER: S-EPMC4498988 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Sanders Rogier W RW van Gils Marit J MJ Derking Ronald R Sok Devin D Ketas Thomas J TJ Burger Judith A JA Ozorowski Gabriel G Cupo Albert A Simonich Cassandra C Goo Leslie L Arendt Heather H Kim Helen J HJ Lee Jeong Hyun JH Pugach Pavel P Williams Melissa M Debnath Gargi G Moldt Brian B van Breemen Mariëlle J MJ Isik Gözde G Medina-Ramírez Max M Back Jaap Willem JW Koff Wayne C WC Julien Jean-Philippe JP Rakasz Eva G EG Seaman Michael S MS Guttman Miklos M Lee Kelly K KK Klasse Per Johan PJ LaBranche Celia C Schief William R WR Wilson Ian A IA Overbaugh Julie J Burton Dennis R DR Ward Andrew B AB Montefiori David C DC Dean Hansi H Moore John P JP
Science (New York, N.Y.) 20150618 6244
A challenge for HIV-1 immunogen design is the difficulty of inducing neutralizing antibodies (NAbs) against neutralization-resistant (tier 2) viruses that dominate human transmissions. We show that a soluble recombinant HIV-1 envelope glycoprotein trimer that adopts a native conformation, BG505 SOSIP.664, induced NAbs potently against the sequence-matched tier 2 virus in rabbits and similar but weaker responses in macaques. The trimer also consistently induced cross-reactive NAbs against more se ...[more]