Ontology highlight
ABSTRACT:
SUBMITTER: Pourhashemi SJ
PROVIDER: S-EPMC4499090 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Pourhashemi S Jalal SJ Ghandehari Motlagh Mehdi M Meighani Ghasem G Ebrahimi Takaloo Azadeh A Mansouri Mahsa M Mohandes Fatemeh F Mirzaii Maryam M Khoshzaban Ahad A Moshtaghi Faranak F Abedkhojasteh Hoda H Heidari Mansour M
Iranian journal of public health 20141201 12
<h4>Background</h4>Amelogenesis Imperfecta (AI) is a disorder of tooth development where there is an abnormal formation of enamel or the external layer of teeth. The aim of this study was to screen mutations in the four most important candidate genes, ENAM, KLK4, MMP20 and FAM83H responsible for amelogenesis imperfect.<h4>Methods</h4>Geneomic DNA was isolated from five Iranian families with 22 members affected with enamel malformations. The PCR amplifications were typically carried out for ampli ...[more]