Ontology highlight
ABSTRACT:
SUBMITTER: Fuse S
PROVIDER: S-EPMC4499250 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20131202 3
The development of highly efficient amide bond forming methods which are devoid of side reactions, including epimerization, is important, and such a method is described herein and is based on the concept of rapid and strong activation of carboxylic acids. Various carboxylic acids are rapidly (0.5 s) converted into highly active species, derived from the inexpensive and less-toxic solid triphosgene, and then rapidly (4.3 s) reacted with various amines to afford the desired peptides in high yields ...[more]