Ontology highlight
ABSTRACT:
SUBMITTER: Zeng Y
PROVIDER: S-EPMC4499844 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Zeng Yan Y Liu Hongtao H Kang Kang K Wang Zhiwei Z Hui Gang G Zhang Xiaoying X Zhong Jiasheng J Peng Wenda W Ramchandran Ramaswamy R Raj J Usha JU Gou Deming D
Scientific reports 20150713
There is growing evidence that microRNAs play important roles in cellular responses to hypoxia and in pulmonary hypertensive vascular remodeling, but the exact molecular mechanisms involved are not fully elucidated. In this study, we identified miR-322 as one of the microRNAs induced in lungs of chronically hypoxic mice and rats. The expression of miR-322 was also upregulated in primary cultured rat pulmonary arterial smooth muscle cells (PASMC) in response to hypoxia. We demonstrated that HIF-1 ...[more]