Ontology highlight
ABSTRACT:
SUBMITTER: Gjorevski N
PROVIDER: S-EPMC4499882 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Gjorevski Nikolce N Piotrowski Alexandra S AS Varner Victor D VD Nelson Celeste M CM
Scientific reports 20150713
Collective cell migration drives tissue remodeling during development, wound repair, and metastatic invasion. The physical mechanisms by which cells move cohesively through dense three-dimensional (3D) extracellular matrix (ECM) remain incompletely understood. Here, we show directly that migration of multicellular cohorts through collagenous matrices occurs via a dynamic pulling mechanism, the nature of which had only been inferred previously in 3D. Tensile forces increase at the invasive front ...[more]