Ontology highlight
ABSTRACT:
SUBMITTER: Nahmias Y
PROVIDER: S-EPMC4500072 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Nahmias Yaakov Y Goldwasser Jonathan J Casali Monica M van Poll Daan D Wakita Takaji T Chung Raymond T RT Yarmush Martin L ML
Hepatology (Baltimore, Md.) 20080501 5
<h4>Unlabelled</h4>Hepatitis C virus (HCV) infects over 3% of the world population and is the leading cause of chronic liver disease worldwide. HCV has long been known to associate with circulating lipoproteins, and its interactions with the cholesterol and lipid pathways have been recently described. In this work, we demonstrate that HCV is actively secreted by infected cells through a Golgi-dependent mechanism while bound to very low density lipoprotein (vLDL). Silencing apolipoprotein B (ApoB ...[more]