Ontology highlight
ABSTRACT:
SUBMITTER: Xia CQ
PROVIDER: S-EPMC4500116 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Xia Chang-Qing CQ Peng Ruihua R Chernatynskaya Anna V AV Yuan Lihui L Carter Carolyn C Valentine John J Sobel Eric E Atkinson Mark A MA Clare-Salzler Michael J MJ
Journal of immunology (Baltimore, Md. : 1950) 20140627 3
Increasing evidence suggests that type 1 IFN (IFN-αβ) is associated with pathogenesis of Th1-mediated type 1 diabetes (T1D). A major source of IFN-αβ is plasmacytoid dendritic cells (pDCs). In this study, we analyzed peripheral blood pDC numbers and functions in at-risk, new-onset, and established T1D patients and controls. We found that subjects at risk for T1D and new-onset and established T1D subjects possessed significantly increased pDCs but similar number of myeloid DCs when compared with ...[more]