Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis.
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ABSTRACT:
SUBMITTER: Xu D
PROVIDER: S-EPMC4500169 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis.
Xu Dazhi D Li Chien-Feng CF Zhang Xian X Gong Zhaohui Z Chan Chia-Hsin CH Lee Szu-Wei SW Jin Guoxiang G Rezaeian Abdol-Hossein AH Han Fei F Wang Jing J Yang Wei-Lei WL Feng Zi-Zhen ZZ Chen Wei W Wu Ching-Yuan CY Wang Ying-Jan YJ Chow Lu-Ping LP Zhu Xiao-Feng XF Zeng Yi-Xin YX Lin Hui-Kuan HK
Nature communications 20150330
Understanding the mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify the Skp2-macroH2A1 (mH2A1)-cyclin-dependent kinase 8 (CDK8) axis as a critical pathway for these processes, and deregulation of this pathway is associated with human breast cancer progression and patient survival outcome. We showed that mH2A1 is a new substrate of Skp2 SCF complex whose degradation by Skp2 promo ...[more]
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