Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications.
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ABSTRACT:
SUBMITTER: Liyanage W
PROVIDER: S-EPMC4500652 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications.
Liyanage Wathsala W Vats Kanika K Rajbhandary Annada A Benoit Danielle S W DS Nilsson Bradley L BL
Chemical communications (Cambridge, England) 20150601 56
Fmoc-3F-Phe-Arg-NH2 and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality. ...[more]
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