Ontology highlight
ABSTRACT:
SUBMITTER: Swanner J
PROVIDER: S-EPMC4501353 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Swanner Jessica J Mims Jade J Carroll David L DL Akman Steven A SA Furdui Cristina M CM Torti Suzy V SV Singh Ravi N RN
International journal of nanomedicine 20150611
Identification of differential sensitivity of cancer cells as compared to normal cells has the potential to reveal a therapeutic window for the use of silver nanoparticles (AgNPs) as a therapeutic agent for cancer therapy. Exposure to AgNPs is known to cause dose-dependent toxicities, including induction of oxidative stress and DNA damage, which can lead to cell death. Triple-negative breast cancer (TNBC) subtypes are more vulnerable to agents that cause oxidative stress and DNA damage than are ...[more]