Ontology highlight
ABSTRACT:
SUBMITTER: Kim DJ
PROVIDER: S-EPMC4501361 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Kim Dae Joong DJ Christofidou Elena D ED Keene Douglas R DR Hassan Milde Marwah M Adams Josephine C JC
Molecular biology of the cell 20150520 14
Thrombospondins participate in many aspects of tissue organization in adult tissue homeostasis, and their dysregulation contributes to pathological processes such as fibrosis and tumor progression. The incorporation of thrombospondins into extracellular matrix (ECM) as discrete puncta has been documented in various tissue and cell biological contexts, yet the underlying mechanisms remain poorly understood. We find that collagen fibrils are disorganized in multiple tissues of Thbs1(-/-) mice. In ...[more]