Ontology highlight
ABSTRACT:
SUBMITTER: Lange A
PROVIDER: S-EPMC4502416 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20061214 8
The best understood system for the transport of macromolecules between the cytoplasm and the nucleus is the classical nuclear import pathway. In this pathway, a protein containing a classical basic nuclear localization signal (NLS) is imported by a heterodimeric import receptor consisting of the beta-karyopherin importin beta, which mediates interactions with the nuclear pore complex, and the adaptor protein importin alpha, which directly binds the classical NLS. Here we review recent studies th ...[more]