Ontology highlight
ABSTRACT:
SUBMITTER: Rovetta AI
PROVIDER: S-EPMC4502660 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Rovetta Ana I AI Peña Delfina D Hernández Del Pino Rodrigo E RE Recalde Gabriela M GM Pellegrini Joaquín J Pellegrini Joaquín J Bigi Fabiana F Musella Rosa M RM Palmero Domingo J DJ Gutierrez Marisa M Colombo María I MI García Verónica E VE
Autophagy 20140101 12
Protective immunity against Mycobacterium tuberculosis (Mtb) requires IFNG. Besides, IFNG-mediated induction of autophagy suppresses survival of virulent Mtb in macrophage cell lines. We investigated the contribution of autophagy to the defense against Mtb antigen (Mtb-Ag) in cells from tuberculosis patients and healthy donors (HD). Patients were classified as high responders (HR) if their T cells produced significant IFNG against Mtb-Ag; and low responders (LR) when patients showed weak or no T ...[more]