Ontology highlight
ABSTRACT:
SUBMITTER: Tang B
PROVIDER: S-EPMC4502731 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Tang Bin B Li Qian Q Zhao Xiu-hua XH Wang Hai-guang HG Li Na N Fang Yao Y Wang Kun K Jia Yin-ping YP Zhu Pan P Gu Jiang J Li Jing-xin JX Jiao Yong-jun YJ Tong Wen-de WD Wang Marissa M Zou Quan-ming QM Zhu Feng-cai FC Mao Xu-hu XH
Autophagy 20150101 2
Shiga toxins (Stxs) are a family of cytotoxic proteins that lead to the development of bloody diarrhea, hemolytic-uremic syndrome, and central nervous system complications caused by bacteria such as S. dysenteriae, E. coli O157:H7 and E. coli O104:H4. Increasing evidence indicates that macroautophagy (autophagy) is a key factor in the cell death induced by Stxs. However, the associated mechanisms are not yet clear. This study showed that Stx2 induces autophagic cell death in Caco-2 cells, a cult ...[more]