Heat shock response and autophagy--cooperation and control.
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ABSTRACT:
SUBMITTER: Dokladny K
PROVIDER: S-EPMC4502786 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Heat shock response and autophagy--cooperation and control.
Dokladny Karol K Myers Orrin B OB Moseley Pope L PL
Autophagy 20150101 2
Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single cells to whole organisms. Cells possess several mechanisms and processes to maintain proteostasis. At one end of the spectrum, the heat shock proteins modulate protein folding and repair. At the other end, the proteasome and autophagy as well as other lysosome-dependent systems, function in the degradation of dysfunctional proteins. In thi ...[more]
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