Management of the first in vitro fertilization cycle for unexplained infertility: a cost-effectiveness analysis of split in vitro fertilization-intracytoplasmic sperm injection.

ABSTRACT:

Objective

To determine the cost-effectiveness of split IVF-intracytoplasmic sperm injection (ICSI) for the treatment of couples with unexplained infertility.

Design

Adaptive decision model.

Setting

Academic infertility clinic.

Patient(s)

A total of 154 couples undergoing a split IVF-ICSI cycle and a computer-simulated cohort of women <35 years old with unexplained infertility undergoing IVF.

Intervention(s)

Modeling insemination method in the first IVF cycle as all IVF, split IVF-ICSI, or all ICSI, and adapting treatment based on fertilization outcomes.

Main outcome measure(s)

Live birth rate, incremental cost-effectiveness ratio (ICER).

Result(s)

In a single cycle, all IVF is preferred as the ICER of split IVF-ICSI or all ICSI ($58,766) do

SUBMITTER: Vitek WS 

PROVIDER: S-EPMC4503359 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature