Ontology highlight
ABSTRACT:
SUBMITTER: Ding J
PROVIDER: S-EPMC4503378 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Ding Jian J Tasker Carley C Lespinasse Pierre P Dai Jihong J Fitzgerald-Bocarsly Patricia P Lu Wuyuan W Heller Debra D Chang Theresa Li-Yun TL
Journal of acquired immune deficiency syndromes (1999) 20150801 5
<h4>Background</h4>CD4 T cells are crucial for the establishment and dissemination of HIV in mucosal tissues during acute infection. Studies indicate that integrin α4β7 CD4 T cells are preferentially infected by HIV in vitro and during acute SIV infection. The integrin α4β7 is thought to promote HIV capture by target cells; however, the role of integrin α4β7 in HIV transmission remains controversial. In this study, we characterized immune phenotypes of human cervical T cells and examined HIV pre ...[more]