Ontology highlight
ABSTRACT:
SUBMITTER: Kim SY
PROVIDER: S-EPMC4503461 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Kim Sun-Yee SY Zhang Qiongyi Q Brunmeir Reinhard R Han Weiping W Xu Feng F
PloS one 20150715 7
SIRT1 plays a key role in maintaining metabolic homeostasis in mammals by directly modulating the activities of various transcription factors and metabolic enzymes through lysine deacetylation. White adipose tissue plays a key role in lipid storage and metabolism. To identify novel molecular targets of SIRT1 in fat cells, we used a non-biased proteomic approach. We identified a number of proteins whose acetylation status was significantly affected by SIRT1 modulator treatment in 3T3-L1 adipocyte ...[more]