Ontology highlight
ABSTRACT:
SUBMITTER: Parekh VI
PROVIDER: S-EPMC4503551 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Parekh Vaishali I VI Modali Sita D SD Desai Shruti S SS Agarwal Sunita K SK
International journal of endocrinology 20150702
Lipoma in patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome is a type of benign fat-cell tumor that has biallelic inactivation of MEN1 that encodes menin and could serve as a model to investigate normal and pathologic fat-cell (adipocyte) proliferation and function. The role of menin and its target genes in adipocytes is not known. We used in vitro differentiation to derive matched normal and menin-deficient adipocytes from wild type (WT) and menin-null (Men1-KO) mouse embryo ...[more]