Ontology highlight
ABSTRACT:
SUBMITTER: Winstedt L
PROVIDER: S-EPMC4503742 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Winstedt Lena L Järnum Sofia S Nordahl Emma Andersson EA Olsson Andreas A Runström Anna A Bockermann Robert R Karlsson Christofer C Malmström Johan J Palmgren Gabriella Samuelsson GS Malmqvist Ulf U Björck Lars L Kjellman Christian C
PloS one 20150715 7
<h4>Unlabelled</h4>IdeS is a streptococcal protease that cleaves IgG antibodies into F(ab’)2 and Fc fragments with a unique degree of specificity, thereby providing a novel treatment opportunity of IgG-driven autoimmune conditions and antibody mediated transplant rejection. Here we report the results from a first in man, double blinded and randomized study with single ascending doses of IdeS in healthy, male subjects. Twenty healthy subjects were given intravenous single ascending doses of IdeS. ...[more]