Ontology highlight
ABSTRACT:
SUBMITTER: Ferrandon S
PROVIDER: S-EPMC4504179 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Ferrandon Sylvain S Malleval Céline C El Hamdani Badia B Battiston-Montagne Priscillia P Bolbos Radu R Langlois Jean-Baptiste JB Manas Patrick P Gryaznov Sergei M SM Alphonse Gersende G Honnorat Jérôme J Rodriguez-Lafrasse Claire C Poncet Delphine D
Molecular cancer 20150717
<h4>Background</h4>Glioblastoma (GBM) is the most frequent and aggressive type of adult brain tumor. Most GBMs express telomerase; a high level of intra-tumoral telomerase activity (TA) is predictive of poor prognosis. Thus, telomerase inhibitors are promising options to treat GBM. These inhibitors increase the response to radiotherapy (RT), in vitro as well as in vivo. Since typical treatments for GBM include RT, our objective was to evaluate the efficiency of Imetelstat (TA inhibitor) combined ...[more]