MDM2-p53 pathway in hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Meng X
PROVIDER: S-EPMC4504428 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
MDM2-p53 pathway in hepatocellular carcinoma.
Meng Xuan X Franklin Derek A DA Dong Jiahong J Zhang Yanping Y
Cancer research 20141204 24
Abnormalities in the TP53 gene and overexpression of MDM2, a transcriptional target and negative regulator of p53, are commonly observed in cancers. The MDM2-p53 feedback loop plays an important role in tumor progression and thus, increased understanding of the pathway has the potential to improve clinical outcomes for cancer patients. Hepatocellular carcinoma (HCC) has emerged as one of the most commonly diagnosed forms of human cancer; yet, the current treatment for HCC is less effective than ...[more]
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