Ontology highlight
ABSTRACT:
SUBMITTER: Park K
PROVIDER: S-EPMC4504680 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20150427 24
Three distinct families of ATP:corrinoid adenosyltransferases (ACATs) exist that are capable of converting vitamin B12 derivatives into coenzyme B12 by catalyzing the thermodynamically challenging reduction of Co(II) rrinoids to form "supernucleophilic" Co(I) intermediates. While the structures and mechanisms of two of the ACAT families have been studied extensively, little is known about the EutT enzymes beyond the fact that they exhibit a unique requirement for a divalent metal cofactor for en ...[more]