Ontology highlight
ABSTRACT:
SUBMITTER: Fuchs JD
PROVIDER: S-EPMC4504730 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Fuchs Jonathan D JD Frank Ian I Elizaga Marnie L ML Allen Mary M Frahm Nicole N Kochar Nidhi N Li Sue S Edupuganti Srilatha S Kalams Spyros A SA Tomaras Georgia D GD Sheets Rebecca R Pensiero Michael M Tremblay Marc A MA Higgins Terry J TJ Latham Theresa T Egan Michael A MA Clarke David K DK Eldridge John H JH Mulligan Mark M Rouphael Nadine N Estep Scharla S Rybczyk Kyle K Dunbar Deb D Buchbinder Susan S Wagner Theresa T Isbell Reese R Chinnell Victoria V Bae Jin J Escamilla Gina G Tseng Jenny J Fair Ramey R Ramirez Shelly S Broder Gail G Briesemeister Liz L Ferrara Adi A
Open forum infectious diseases 20150605 3
Background. We report the first-in-human safety and immunogenicity evaluation of a highly attenuated, replication-competent recombinant vesicular stomatitis virus (rVSV) human immunodeficiency virus (HIV)-1 vaccine. Methods. Sixty healthy, HIV-1-uninfected adults were enrolled in a randomized, double-blinded, placebo-controlled dose-escalation study. Groups of 12 participants received rVSV HIV-1 gag vaccine at 5 dose levels (4.6 × 10(3) to 3.4 × 10(7) particle forming units) (N = 10/group) or ...[more]