Ontology highlight
ABSTRACT:
SUBMITTER: Khan AG
PROVIDER: S-EPMC4505365 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Khan Abdul Ghafoor AG Miller Matthew T MT Marcotrigiano Joseph J
Current opinion in virology 20150316
Hepatitis C virus (HCV) is continuing to spread worldwide, adding three million new infections each year. Currently approved therapies are highly effective; however, access to them is limited due to the high cost of treatment. Therefore, a cost effective vaccine and alternative antivirals remain essential. HCV envelope glycoproteins, E1 and E2, heterodimerize on the virion surface and are the major determinant for virus pathogenicity and host immune response. Recent structural insights into amin ...[more]