Ontology highlight
ABSTRACT:
SUBMITTER: Rahaman MM
PROVIDER: S-EPMC4505432 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Rahaman Md Mizanur MM Reinders Fabio G FG Koes David D Nguyen Anh T AT Mutchler Stephanie M SM Sparacino-Watkins Courtney C Alvarez Roger A RA Miller Megan P MP Cheng Dongmei D Chen Bill B BB Jackson Edwin K EK Camacho Carlos J CJ Straub Adam C AC
The Journal of biological chemistry 20150522 27
NADH cytochrome b5 reductase 3 (CYB5R3) is critical for reductive reactions such as fatty acid elongation, cholesterol biosynthesis, drug metabolism, and methemoglobin reduction. Although the physiological and metabolic importance of CYB5R3 has been established in hepatocytes and erythrocytes, emerging investigations suggest that CYB5R3 is critical for nitric oxide signaling and vascular function. However, advancement toward fully understanding CYB5R3 function has been limited due to a lack of p ...[more]