Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors.
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ABSTRACT:
SUBMITTER: Wong JH
PROVIDER: S-EPMC4505548 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Publications
Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors.
Wong Jessica H JH Sahni Urvashi U Li Yanhong Y Chen Xi X Gervay-Hague Jacquelyn J
Organic & biomolecular chemistry 20081117 1
A modular replacement approach to the synthesis of sulfo-nucleotide analogs prepared from condensation of nucleoside aldehydes with bis phosphonate Horner-Wadsworth-Emmons reagents is disclosed. These analogs were shown to be inhibitors of Neisseria meningitidis CSS (NmCSS), which is a key enzyme in the biosynthesis of the capsular polysaccharides required for bacterial infection. ...[more]
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