Ontology highlight
ABSTRACT:
SUBMITTER: Trakhtenberg EF
PROVIDER: S-EPMC4505589 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20150401 21
Set-β protein plays different roles in neurons, but the diversity of Set-β neuronal isoforms and their functions have not been characterized. The expression and subcellular localization of Set-β are altered in Alzheimer disease, cleavage of Set-β leads to neuronal death after stroke, and the full-length Set-β regulates retinal ganglion cell (RGC) and hippocampal neuron axon growth and regeneration in a subcellular localization-dependent manner. Here we used various biochemical approaches to inve ...[more]