Strategies for developing multi-epitope, subunit-based, chemically synthesized anti-malarial vaccines.
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ABSTRACT:
SUBMITTER: Patarroyo ME
PROVIDER: S-EPMC4506160 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
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Strategies for developing multi-epitope, subunit-based, chemically synthesized anti-malarial vaccines.
Patarroyo M E ME Cifuentes G G Bermúdez A A Patarroyo M A MA
Journal of cellular and molecular medicine 20081001 5B
An anti-malarial vaccine against the extremely lethal Plasmodium falciparum is desperately needed. Peptides from this parasite's proteins involved in invasion and having high red blood cell-binding ability were identified; these conserved peptides were not immunogenic or protection-inducing when used for immunizing Aotus monkeys. Modifying some critical binding residues in these high-activiy binding peptides' (HABPs') attachment to red blood cells (RBC) allowed them to induce immunogenicity and ...[more]
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