Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
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ABSTRACT:
SUBMITTER: Talbot S
PROVIDER: S-EPMC4506220 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
Talbot Sébastien S Abdulnour Raja-Elie E RE Burkett Patrick R PR Lee Seungkyu S Cronin Shane J F SJ Pascal Maud A MA Laedermann Cedric C Foster Simmie L SL Tran Johnathan V JV Lai Nicole N Chiu Isaac M IM Ghasemlou Nader N DiBiase Matthew M Roberson David D Von Hehn Christian C Agac Busranour B Haworth Oliver O Seki Hiroyuki H Penninger Josef M JM Kuchroo Vijay K VK Bean Bruce P BP Levy Bruce D BD Woolf Clifford J CJ
Neuron 20150625 2
Lung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also contribute to allergic airway inflammation, we stimulated lung nociceptors with capsaicin and observed increased neuropeptide release and immune cell infiltration. In contrast, ablating Nav1.8(+) sensory neurons or silencing them with QX-314, a charged sodium channel inhibitor that enters via large-pore ion channels to specifically block nociceptors, substantially reduced ovalbumin- or house-dust-mite-indu ...[more]
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