Ontology highlight
ABSTRACT:
SUBMITTER: Katz SC
PROVIDER: S-EPMC4506253 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Katz Steven C SC Burga Rachel A RA McCormack Elise E Wang Li Juan LJ Mooring Wesley W Point Gary R GR Khare Pranay D PD Thorn Mitchell M Ma Qiangzhong Q Stainken Brian F BF Assanah Earle O EO Davies Robin R Espat N Joseph NJ Junghans Richard P RP
Clinical cancer research : an official journal of the American Association for Cancer Research 20150407 14
<h4>Purpose</h4>Chimeric antigen receptor-modified T cells (CAR-T) have demonstrated encouraging results in early-phase clinical trials. Successful adaptation of CAR-T technology for CEA-expressing adenocarcinoma liver metastases, a major cause of death in patients with gastrointestinal cancers, has yet to be achieved. We sought to test intrahepatic delivery of anti-CEA CAR-T through percutaneous hepatic artery infusions (HAIs).<h4>Experimental design</h4>We conducted a phase I trial to test HAI ...[more]