Ontology highlight
ABSTRACT:
SUBMITTER: Minster RL
PROVIDER: S-EPMC4506316 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Minster Ryan L RL Sanders Jason L JL Singh Jatinder J Kammerer Candace M CM Barmada M Michael MM Matteini Amy M AM Zhang Qunyuan Q Wojczynski Mary K MK Daw E Warwick EW Brody Jennifer A JA Arnold Alice M AM Lunetta Kathryn L KL Murabito Joanne M JM Christensen Kaare K Perls Thomas T TT Province Michael A MA Newman Anne B AB
The journals of gerontology. Series A, Biological sciences and medical sciences 20150310 8
<h4>Background</h4>The Healthy Aging Index (HAI) is a tool for measuring the extent of health and disease across multiple systems.<h4>Methods</h4>We conducted a genome-wide association study and a genome-wide linkage analysis to map quantitative trait loci associated with the HAI and a modified HAI weighted for mortality risk in 3,140 individuals selected for familial longevity from the Long Life Family Study. The genome-wide association study used the Long Life Family Study as the discovery coh ...[more]