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Atg1 family kinases in autophagy initiation.

ABSTRACT: Autophagosome formation, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. Among all Atg proteins, Atg1 kinase in yeast and its counterpart in higher eukaryotes, ULK1 kinase, function as the most upstream factor in this process and mediate autophagy initiation. In this review, we summarize current knowledge of the structure, molecular function, and regulation of Atg1 family kinases in the initiation of autophagy.

SUBMITTER: Noda NN

PROVIDER: S-EPMC4506457 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Atg1 family kinases in autophagy initiation.

Noda Nobuo N NN Fujioka Yuko Y

Cellular and molecular life sciences : CMLS 20150507 16

Autophagosome formation, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. Among all Atg proteins, Atg1 kinase in yeast and its counterpart in higher eukaryotes, ULK1 kinase, function as the most upstream factor in this process and mediate autophagy initiation. In this review, we summarize current knowledge of the structure, molecular function, and regulation of Atg1 family kinases in the initiation of autophagy. ...[more]

PMID: 25948417

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